ctcRbase

Entry Detail

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General Information

Database ID: BRCA03872 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: EIF4E Full Name: eukaryotic translation initiation factor 4E Category: mRNA Synonyms: AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E Chromosome: chr4 Strand: - Coordinate: Start Site(bp): 98871684 End Site(bp): 98930637 Gene Summary: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000151247 HGNC ID: HGNC:3287 Entrez Gene: 1977

Expression Profile of EIF4E Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-205-5p YES NO YES hsa-miR-206 YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-424-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-499a-5p NO YES YES hsa-miR-503-5p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-599 YES YES NO hsa-miR-613 YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-7-5p NO YES YES hsa-miR-873-5p YES YES YES Display: