ctcRbase

Entry Detail

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General Information

Database ID: BRCA03903 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CDK2AP1 Full Name: cyclin dependent kinase 2 associated protein 1 Category: mRNA Synonyms: DOC1|DORC1|ST19|doc-1|p12DOC-1 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 123260971 End Site(bp): 123272334 Gene Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000111328 HGNC ID: HGNC:14002 Entrez Gene: 8099

Expression Profile of CDK2AP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES YES hsa-miR-139-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-590-5p YES YES NO Display: