ctcRbase

Entry Detail

---



General Information

Database ID: BRCA03909 Cancer Type: breast cancer Dataset: GSE67939 CTCs/CTM Isolation Method: Cluster-Chip

Gene Information

ncRNA Symbol: VCL Full Name: vinculin Category: mRNA Synonyms: CMD1W|CMH15|HEL114|MV|MVCL Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 73995193 End Site(bp): 74121363 Gene Summary: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000035403 HGNC ID: HGNC:12665 Entrez Gene: 7414

Expression Profile of VCL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-1197 YES NO YES hsa-miR-124-3p YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-137 YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-193a-5p YES NO YES hsa-miR-195-5p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-346 YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-7-5p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES YES hsa-miR-98-5p YES YES NO Display: