ctcRbase

Entry Detail

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General Information

Database ID: BRCA03928 Cancer Type: breast cancer Dataset: GSE51827 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: BCL2L1 Full Name: BCL2 like 1 Category: mRNA Synonyms: BCL-XL/S|BCL2L|BCLX|Bcl-X|PPP1R52 Chromosome: chr20 Strand: - Coordinate: Start Site(bp): 31664452 End Site(bp): 31723989 Gene Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015] External Links: Ensembl ID: ENSG00000171552 HGNC ID: HGNC:992 Entrez Gene: 598

Expression Profile of BCL2L1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-140-5p YES YES YES hsa-miR-142-3p YES NO YES hsa-miR-184 YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-7-5p YES NO YES hsa-miR-98-5p YES YES YES Display: