| ncRNA Symbol: | SF3B2 |
| Full Name: | splicing factor 3b subunit 2 |
| Category: | mRNA |
| Synonyms: | Cus1|SAP145|SF3B145|SF3b1|SF3b150 |
| Chromosome: | chr11 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 66050729 | End Site(bp): | 66069308 |
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| Gene Summary: | This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008] |
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