| ncRNA Symbol: | SURF1 | | Full Name: | SURF1, cytochrome c oxidase assembly factor | | Category: | mRNA | | Synonyms: | CMT4K | | Chromosome: | chr9 | | Strand: | - | | Coordinate: | | Start Site(bp): | 133351755 | End Site(bp): | 133356676 |
| | Gene Summary: | This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008] | | External Links: | |
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