ctcRbase

Entry Detail

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General Information

Database ID: BRCA04051 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: INSIG1 Full Name: insulin induced gene 1 Category: mRNA Synonyms: CL6 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 155297776 End Site(bp): 155310235 Gene Summary: This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] External Links: Ensembl ID: ENSG00000186480 HGNC ID: HGNC:6083 Entrez Gene: 3638

Expression Profile of INSIG1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-183-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-208a-3p YES NO YES hsa-miR-208b-3p YES NO YES hsa-miR-210-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-219a-5p YES YES YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-384 YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-496 YES YES YES hsa-miR-499a-5p YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-665 YES NO YES hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES NO Display: