ctcRbase

Entry Detail

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General Information

Database ID: BRCA04060 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SPG21 Full Name: SPG21, maspardin Category: mRNA Synonyms: ACP33|BM-019|GL010|MAST Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 64963021 End Site(bp): 64990310 Gene Summary: The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] External Links: Ensembl ID: ENSG00000090487 HGNC ID: HGNC:20373 Entrez Gene: 51324

Expression Profile of SPG21 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES NO NO hsa-miR-300 YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-543 YES YES NO Display: