ctcRbase

Entry Detail

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General Information

Database ID: BRCA04067 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: NXF1 Full Name: nuclear RNA export factor 1 Category: mRNA Synonyms: MEX67|TAP Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 62792123 End Site(bp): 62806302 Gene Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000162231 HGNC ID: HGNC:8071 Entrez Gene: 10482

Expression Profile of NXF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES NO YES hsa-miR-128-3p YES NO YES hsa-miR-130b-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-28-5p YES NO YES hsa-miR-301b-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-491-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-642a-5p YES NO NO hsa-miR-665 YES NO YES hsa-miR-708-5p YES NO YES hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES NO Display: