ctcRbase

Entry Detail

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General Information

Database ID: BRCA04086 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MAP2K3 Full Name: mitogen-activated protein kinase kinase 3 Category: mRNA Synonyms: MAPKK3|MEK3|MKK3|PRKMK3|SAPKK-2|SAPKK2 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 21284672 End Site(bp): 21315240 Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000034152 HGNC ID: HGNC:6843 Entrez Gene: 5606

Expression Profile of MAP2K3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-195-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-21-5p YES NO YES hsa-miR-339-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-590-5p YES YES YES hsa-miR-9-5p YES NO YES hsa-miR-96-5p YES YES YES Display: