ctcRbase

Entry Detail

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General Information

Database ID: BRCA04301 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: YBX1 Full Name: Y-box binding protein 1 Category: mRNA Synonyms: BP-8|CBF-A|CSDA2|CSDB|DBPB|EFI-A|MDR-NF1|NSEP-1|NSEP1|YB-1|YB1 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 42682427 End Site(bp): 42702349 Gene Summary: This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000065978 HGNC ID: HGNC:8014 Entrez Gene: 4904

Expression Profile of YBX1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES YES hsa-miR-1297 YES YES NO hsa-miR-137 YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-375 YES YES YES hsa-miR-379-5p YES YES YES hsa-miR-382-5p YES YES YES hsa-miR-494-3p YES YES YES hsa-miR-499a-5p YES YES YES hsa-miR-505-3p YES YES NO Display: