ctcRbase

Entry Detail

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General Information

Database ID: BRCA04371 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: HSBP1 Full Name: heat shock factor binding protein 1 Category: mRNA Synonyms: NPC-A-13 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 83807843 End Site(bp): 83819737 Gene Summary: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000230989 HGNC ID: HGNC:5203 Entrez Gene: 3281

Expression Profile of HSBP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES NO YES hsa-miR-1297 YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-448 YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-876-5p YES YES YES hsa-miR-96-5p YES NO YES Display: