ctcRbase

Entry Detail

---



General Information

Database ID: BRCA04475 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PRKAR1A Full Name: protein kinase cAMP-dependent type I regulatory subunit alpha Category: mRNA Synonyms: ACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 68511780 End Site(bp): 68551319 Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013] External Links: Ensembl ID: ENSG00000108946 HGNC ID: HGNC:9388 Entrez Gene: 5573

Expression Profile of PRKAR1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-141-3p YES YES YES hsa-miR-150-5p YES YES YES hsa-miR-155-5p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-192-5p YES YES YES hsa-miR-194-5p YES NO YES hsa-miR-195-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-215-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-668-3p YES NO YES hsa-miR-802 YES NO YES hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES NO Display: