ctcRbase

Entry Detail

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General Information

Database ID: BRCA04497 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SELENOT Full Name: selenoprotein T Category: mRNA Synonyms: SELT Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 150602875 End Site(bp): 150630445 Gene Summary: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017] External Links: Ensembl ID: ENSG00000198843 HGNC ID: HGNC:18136 Entrez Gene: 51714

Expression Profile of SELENOT Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-137 YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-21-5p YES YES NO hsa-miR-223-3p YES NO YES hsa-miR-25-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: