ctcRbase

Entry Detail

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General Information

Database ID: BRCA04522 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: RAD50 Full Name: RAD50 double strand break repair protein Category: mRNA Synonyms: NBSLD|RAD502|hRad50 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 132556019 End Site(bp): 132646344 Gene Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010] External Links: Ensembl ID: ENSG00000113522 HGNC ID: HGNC:9816 Entrez Gene: 10111

Expression Profile of RAD50 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-485-5p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-506-3p YES YES NO Display: