ctcRbase

Entry Detail

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General Information

Database ID: BRCA04560 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: SKIL Full Name: SKI like proto-oncogene Category: mRNA Synonyms: SNO|SnoA|SnoI|SnoN Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 170357678 End Site(bp): 170396835 Gene Summary: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000136603 HGNC ID: HGNC:10897 Entrez Gene: 6498

Expression Profile of SKIL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-186-5p YES YES NO hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p NO YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: