ctcRbase

Entry Detail

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General Information

Database ID: BRCA04623 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CSE1L Full Name: chromosome segregation 1 like Category: mRNA Synonyms: CAS|CSE1|XPO2 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 49046246 End Site(bp): 49096960 Gene Summary: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] External Links: Ensembl ID: ENSG00000124207 HGNC ID: HGNC:2431 Entrez Gene: 1434

Expression Profile of CSE1L Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES YES hsa-miR-137 YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-384 YES YES NO hsa-miR-429 YES YES NO hsa-miR-876-5p YES YES NO Display: