ctcRbase

Entry Detail

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General Information

Database ID: BRCA04743 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: COX7A2L Full Name: cytochrome c oxidase subunit 7A2 like Category: mRNA Synonyms: COX7AR|COX7RP|EB1|SIG81 Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 42333546 End Site(bp): 42425088 Gene Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000115944 HGNC ID: HGNC:2289 Entrez Gene: 9167

Expression Profile of COX7A2L Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-217 YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-384 YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-543 YES YES NO hsa-miR-93-5p YES YES YES Display: