ctcRbase

Entry Detail

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General Information

Database ID: BRCA04810 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CAMKK2 Full Name: calcium/calmodulin dependent protein kinase kinase 2 Category: mRNA Synonyms: CAMKK|CAMKKB Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 121237691 End Site(bp): 121298308 Gene Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000110931 HGNC ID: HGNC:1470 Entrez Gene: 10645

Expression Profile of CAMKK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1197 YES NO YES hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-129-2-3p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-143-3p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-378a-3p YES YES YES hsa-miR-411-5p YES NO YES hsa-miR-421 YES YES NO hsa-miR-422a YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-876-5p YES YES YES hsa-miR-96-5p YES YES YES Display: