ctcRbase

Entry Detail

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General Information

Database ID: BRCA04831 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: GRB2 Full Name: growth factor receptor bound protein 2 Category: mRNA Synonyms: ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 75318076 End Site(bp): 75405709 Gene Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000177885 HGNC ID: HGNC:4566 Entrez Gene: 2885

Expression Profile of GRB2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-378a-3p YES YES YES hsa-miR-422a YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-96-5p YES YES YES Display: