ctcRbase

Entry Detail

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General Information

Database ID: BRCA04957 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PDCD6IP Full Name: programmed cell death 6 interacting protein Category: mRNA Synonyms: AIP1|ALIX|DRIP4|HP95 Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 33798352 End Site(bp): 33869707 Gene Summary: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012] External Links: Ensembl ID: ENSG00000170248 HGNC ID: HGNC:8766 Entrez Gene: 10015

Expression Profile of PDCD6IP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-137 YES NO YES hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES NO YES hsa-miR-217 YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-25-3p YES NO YES hsa-miR-296-3p YES YES NO hsa-miR-323a-3p YES NO NO hsa-miR-32-5p YES NO YES hsa-miR-328-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-378a-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-422a YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES hsa-miR-9-5p YES YES YES Display: