ctcRbase

Entry Detail

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General Information

Database ID: BRCA05006 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: OTUB1 Full Name: OTU deubiquitinase, ubiquitin aldehyde binding 1 Category: mRNA Synonyms: HSPC263|OTB1|OTU1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 63985853 End Site(bp): 64001811 Gene Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000167770 HGNC ID: HGNC:23077 Entrez Gene: 55611

Expression Profile of OTUB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-28-5p YES NO YES hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-542-3p YES YES YES hsa-miR-708-5p YES NO YES Display: