ctcRbase

Entry Detail

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General Information

Database ID: BRCA05103 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: SEPHS2 Full Name: selenophosphate synthetase 2 Category: mRNA Synonyms: SPS2 Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 30443631 End Site(bp): 30446181 Gene Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017] External Links: Ensembl ID: ENSG00000179918 HGNC ID: HGNC:19686 Entrez Gene: 22928

Expression Profile of SEPHS2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-147a YES NO NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-760 YES NO YES hsa-miR-9-5p YES YES NO Display: