ctcRbase

Entry Detail

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General Information

Database ID: BRCA05210 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PTPA Full Name: protein phosphatase 2 phosphatase activator Category: mRNA Synonyms: PP2A|PPP2R4|PR53 Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 129110950 End Site(bp): 129148946 Gene Summary: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000119383 HGNC ID: HGNC:9308 Entrez Gene: 5524

Expression Profile of PTPA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-150-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-222-3p YES YES NO hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-9-5p YES YES YES Display: