| ncRNA Symbol: | ITGB3BP |
| Full Name: | integrin subunit beta 3 binding protein |
| Category: | mRNA |
| Synonyms: | CENP-R|CENPR|HSU37139|NRIF3|TAP20 |
| Chromosome: | chr1 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 63440770 | End Site(bp): | 63593721 |
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| Gene Summary: | This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
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