| ncRNA Symbol: | MCM4 |
| Full Name: | minichromosome maintenance complex component 4 |
| Category: | mRNA |
| Synonyms: | CDC21|CDC54|IMD54|NKCD|NKGCD|P1-CDC21|hCdc21 |
| Chromosome: | chr8 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 47960185 | End Site(bp): | 47978160 |
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| Gene Summary: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
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