ctcRbase

Entry Detail

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General Information

Database ID: BRCA05440 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: HBS1L Full Name: HBS1 like translational GTPase Category: mRNA Synonyms: EF-1a|ERFS|HBS1|HSPC276|eRF3c Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 134960378 End Site(bp): 135103056 Gene Summary: This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009] External Links: Ensembl ID: ENSG00000112339 HGNC ID: HGNC:4834 Entrez Gene: 10767

Expression Profile of HBS1L Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-130a-3p NO YES YES hsa-miR-130b-3p NO YES YES hsa-miR-148a-3p NO YES YES hsa-miR-148b-3p NO YES YES hsa-miR-152-3p NO YES YES hsa-miR-217 YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-301a-3p NO YES YES hsa-miR-301b-3p NO YES YES hsa-miR-30a-5p NO YES YES hsa-miR-30b-5p NO YES YES hsa-miR-30c-5p NO YES YES hsa-miR-30d-5p NO YES YES hsa-miR-30e-5p NO YES YES hsa-miR-32-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-433-3p YES YES YES hsa-miR-454-3p NO YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: