ctcRbase

Entry Detail

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General Information

Database ID: BRCA05461 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: MRPL43 Full Name: mitochondrial ribosomal protein L43 Category: mRNA Synonyms: L43mt|MRP-L43|bMRP36a Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 100969458 End Site(bp): 100987515 Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000055950 HGNC ID: HGNC:14517 Entrez Gene: 84545

Expression Profile of MRPL43 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-93-5p YES YES NO Display: