ctcRbase

Entry Detail

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General Information

Database ID: BRCA05514 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CARD8 Full Name: caspase recruitment domain family member 8 Category: mRNA Synonyms: CARDINAL|DACAR|DAKAR|NDPP|NDPP1|TUCAN Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 48180770 End Site(bp): 48255946 Gene Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] External Links: Ensembl ID: ENSG00000105483 HGNC ID: HGNC:17057 Entrez Gene: 22900

Expression Profile of CARD8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-122-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES YES NO hsa-miR-93-5p YES YES NO Display: