ctcRbase

Entry Detail

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General Information

Database ID: BRCA05553 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: IBTK Full Name: inhibitor of Bruton tyrosine kinase Category: mRNA Synonyms: BTBD26|BTKI Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 82169983 End Site(bp): 82247754 Gene Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] External Links: Ensembl ID: ENSG00000005700 HGNC ID: HGNC:17853 Entrez Gene: 25998

Expression Profile of IBTK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-137 YES NO YES hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-365a-3p YES YES NO hsa-miR-367-3p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: