ctcRbase

Entry Detail

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General Information

Database ID: BRCA05695 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: BCL10 Full Name: BCL10, immune signaling adaptor Category: mRNA Synonyms: CARMEN|CIPER|CLAP|IMD37|c-E10|mE10 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 85266248 End Site(bp): 85277090 Gene Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] External Links: Ensembl ID: ENSG00000142867 HGNC ID: HGNC:989 Entrez Gene: 8915

Expression Profile of BCL10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-155-5p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-342-3p YES YES NO hsa-miR-375 YES YES NO hsa-miR-384 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-873-5p YES YES NO Display: