ctcRbase

Entry Detail

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General Information

Database ID: BRCA05948 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: ELOC Full Name: elongin C Category: mRNA Synonyms: SIII|TCEB1 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 73939169 End Site(bp): 73972287 Gene Summary: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011] External Links: Ensembl ID: ENSG00000154582 HGNC ID: HGNC:11617 Entrez Gene: 6921

Expression Profile of ELOC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-139-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-217 YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES YES hsa-miR-96-5p YES YES NO Display: