ctcRbase

Entry Detail

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General Information

Database ID: BRCA05962 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: STAT3 Full Name: signal transducer and activator of transcription 3 Category: mRNA Synonyms: ADMIO|ADMIO1|APRF|HIES Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 42313324 End Site(bp): 42388568 Gene Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000168610 HGNC ID: HGNC:11364 Entrez Gene: 6774

Expression Profile of STAT3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-21-5p YES YES YES hsa-miR-296-5p YES NO YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-370-3p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-590-5p YES YES YES hsa-miR-665 YES NO YES hsa-miR-874-3p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES NO YES Display: