ctcRbase

Entry Detail

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General Information

Database ID: BRCA06001 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MECOM Full Name: MDS1 and EVI1 complex locus Category: mRNA Synonyms: AML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 169083499 End Site(bp): 169663618 Gene Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] External Links: Ensembl ID: ENSG00000085276 HGNC ID: HGNC:3498 Entrez Gene: 2122

Expression Profile of MECOM Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-133a-3p YES YES YES hsa-miR-133b YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-140-5p YES NO YES hsa-miR-182-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-206 YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-219a-5p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-338-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-96-5p YES YES YES Display: