ctcRbase

Entry Detail

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General Information

Database ID: BRCA06107 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: BAG4 Full Name: BCL2 associated athanogene 4 Category: mRNA Synonyms: BAG-4|SODD Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 38176533 End Site(bp): 38213301 Gene Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] External Links: Ensembl ID: ENSG00000156735 HGNC ID: HGNC:940 Entrez Gene: 9530

Expression Profile of BAG4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-137 YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-194-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-217 YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-370-3p YES YES YES hsa-miR-384 YES YES NO hsa-miR-421 YES YES NO hsa-miR-429 YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES NO Display: