ctcRbase

Entry Detail

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General Information

Database ID: BRCA06180 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: DKC1 Full Name: dyskerin pseudouridine synthase 1 Category: mRNA Synonyms: CBF5|DKC|DKCX|NAP57|NOLA4|XAP101 Chromosome: chrX Strand: + Coordinate: Start Site(bp): 154762742 End Site(bp): 154777689 Gene Summary: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000130826 HGNC ID: HGNC:2890 Entrez Gene: 1736

Expression Profile of DKC1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-362-5p YES NO YES hsa-miR-371a-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-873-5p YES YES NO Display: