ctcRbase

Entry Detail

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General Information

Database ID: BRCA06198 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PSMD12 Full Name: proteasome 26S subunit, non-ATPase 12 Category: mRNA Synonyms: Rpn5|STISS|p55 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 67337916 End Site(bp): 67366627 Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000197170 HGNC ID: HGNC:9557 Entrez Gene: 5718

Expression Profile of PSMD12 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-425-5p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-599 YES YES NO Display: