ctcRbase

Entry Detail

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General Information

Database ID: BRCA06247 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PSMF1 Full Name: proteasome inhibitor subunit 1 Category: mRNA Synonyms: PI31 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 1113263 End Site(bp): 1189415 Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000125818 HGNC ID: HGNC:9571 Entrez Gene: 9491

Expression Profile of PSMF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-107 YES NO YES hsa-miR-138-5p YES YES YES hsa-miR-140-5p YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES YES hsa-miR-28-5p YES NO YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-665 YES NO YES hsa-miR-708-5p YES NO YES hsa-miR-760 YES NO YES Display: