ctcRbase

Entry Detail

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General Information

Database ID: BRCA06359 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: DDIT3 Full Name: DNA damage inducible transcript 3 Category: mRNA Synonyms: AltDDIT3|C/EBPzeta|CEBPZ|CHOP|CHOP-10|CHOP10|GADD153 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 57516588 End Site(bp): 57520517 Gene Summary: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000175197 HGNC ID: HGNC:2726 Entrez Gene: 1649

Expression Profile of DDIT3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-142-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-96-5p YES YES YES Display: