ctcRbase

Entry Detail

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General Information

Database ID: BRCA06399 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SF3B3 Full Name: splicing factor 3b subunit 3 Category: mRNA Synonyms: RSE1|SAP130|SF3b130|STAF130 Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 70523788 End Site(bp): 70577670 Gene Summary: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000189091 HGNC ID: HGNC:10770 Entrez Gene: 23450

Expression Profile of SF3B3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES NO YES hsa-miR-411-5p YES NO YES hsa-miR-532-3p YES NO YES hsa-miR-543 YES NO YES hsa-miR-625-5p YES NO NO Display: