ctcRbase

Entry Detail

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General Information

Database ID: BRCA06535 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PSME3 Full Name: proteasome activator subunit 3 Category: mRNA Synonyms: HEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 42824385 End Site(bp): 42843758 Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000131467 HGNC ID: HGNC:9570 Entrez Gene: 10197

Expression Profile of PSME3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES NO hsa-miR-151a-3p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-191-5p YES YES NO hsa-miR-194-5p YES NO YES hsa-miR-195-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-324-5p YES YES YES hsa-miR-328-3p NO NO YES hsa-miR-329-3p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO Display: