ctcRbase

Entry Detail

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General Information

Database ID: BRCA06615 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: TSN Full Name: translin Category: mRNA Synonyms: BCLF-1|C3PO|RCHF1|REHF-1|TBRBP|TRSLN Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 121737103 End Site(bp): 121767853 Gene Summary: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000211460 HGNC ID: HGNC:12379 Entrez Gene: 7247

Expression Profile of TSN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-137 YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p NO YES YES hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-376a-3p NO YES YES hsa-miR-376b-3p NO YES YES hsa-miR-421 YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO Display: