ctcRbase

Entry Detail

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General Information

Database ID: BRCA06784 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MCFD2 Full Name: multiple coagulation factor deficiency 2 Category: mRNA Synonyms: F5F8D|F5F8D2|LMAN1IP|SDNSF Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 46901870 End Site(bp): 46941855 Gene Summary: This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016] External Links: Ensembl ID: ENSG00000180398 HGNC ID: HGNC:18451 Entrez Gene: 90411

Expression Profile of MCFD2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-107 YES NO YES hsa-miR-129-2-3p YES NO YES hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-139-5p YES NO YES hsa-miR-142-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-186-5p YES NO YES hsa-miR-195-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-3p YES NO YES hsa-miR-199b-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-33a-5p YES NO YES hsa-miR-33b-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES NO YES hsa-miR-34c-5p YES NO YES hsa-miR-369-3p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-449a YES NO YES hsa-miR-449b-5p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-653-5p YES YES NO Display: