ctcRbase

Entry Detail

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General Information

Database ID: BRCA06890 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: VAV3 Full Name: vav guanine nucleotide exchange factor 3 Category: mRNA Synonyms: - Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 107571160 End Site(bp): 107965144 Gene Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000134215 HGNC ID: HGNC:12659 Entrez Gene: 10451

Expression Profile of VAV3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-122-5p YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-129-2-3p YES NO YES hsa-miR-154-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-223-3p YES NO YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-338-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-499a-5p YES YES YES hsa-miR-543 YES YES YES hsa-miR-758-3p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-98-5p YES NO YES Display: