ctcRbase

Entry Detail

---



General Information

Database ID: BRCA06980 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: ADGRL1 Full Name: adhesion G protein-coupled receptor L1 Category: mRNA Synonyms: CIRL1|CL1|LEC2|LPHN1 Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 14147743 End Site(bp): 14206187 Gene Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000072071 HGNC ID: HGNC:20973 Entrez Gene: 22859

Expression Profile of ADGRL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES NO YES hsa-miR-1271-5p YES NO YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES NO YES hsa-miR-138-5p YES NO YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-182-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-218-5p YES YES YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-28-5p YES YES YES hsa-miR-296-5p YES NO YES hsa-miR-300 YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-375 YES NO YES hsa-miR-381-3p YES YES YES hsa-miR-424-5p YES NO YES hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES NO YES hsa-miR-551a YES YES YES hsa-miR-551b-3p YES YES YES hsa-miR-708-5p YES YES YES hsa-miR-873-5p YES NO YES hsa-miR-96-5p YES NO YES Display: