ctcRbase

Entry Detail

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General Information

Database ID: BRCA07377 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: GREM1 Full Name: gremlin 1, DAN family BMP antagonist Category: mRNA Synonyms: C15DUPq|CKTSF1B1|CRAC1|CRCS4|DAND2|DRM|DUP15q|GREMLIN|HMPS|HMPS1|IHG-2|MPSH|PIG2 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 32717974 End Site(bp): 32745107 Gene Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000166923 HGNC ID: HGNC:2001 Entrez Gene: 26585

Expression Profile of GREM1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1224-5p YES NO YES hsa-miR-1271-5p YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-137 YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-328-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-543 YES YES YES hsa-miR-613 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-7-5p YES YES NO hsa-miR-96-5p YES YES NO Display: