ctcRbase

Entry Detail

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General Information

Database ID: BRCA07385 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: FUBP1 Full Name: far upstream element binding protein 1 Category: mRNA Synonyms: FBP|FUBP|hDH V Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 77944055 End Site(bp): 77979110 Gene Summary: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000162613 HGNC ID: HGNC:4004 Entrez Gene: 8880

Expression Profile of FUBP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-206 YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-346 YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-613 YES YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: