ctcRbase

Entry Detail

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General Information

Database ID: BRCA07405 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: UBE2D2 Full Name: ubiquitin conjugating enzyme E2 D2 Category: mRNA Synonyms: E2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5B Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 139526431 End Site(bp): 139628433 Gene Summary: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] External Links: Ensembl ID: ENSG00000131508 HGNC ID: HGNC:12475 Entrez Gene: 7322

Expression Profile of UBE2D2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-193a-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-375 YES YES NO hsa-miR-376a-3p YES YES YES hsa-miR-376b-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-7-5p YES YES NO Display: