ctcRbase

Entry Detail

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General Information

Database ID: BRCA07530 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PDHB Full Name: pyruvate dehydrogenase E1 beta subunit Category: mRNA Synonyms: PDHBD|PDHE1-B|PDHE1B|PHE1B Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 58427630 End Site(bp): 58433857 Gene Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000168291 HGNC ID: HGNC:8808 Entrez Gene: 5162

Expression Profile of PDHB Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p NO YES YES hsa-let-7b-5p NO YES YES hsa-let-7c-5p NO YES YES hsa-let-7d-5p NO YES YES hsa-let-7e-5p NO YES YES hsa-let-7f-5p NO YES YES hsa-let-7g-5p NO YES YES hsa-let-7i-5p NO YES YES hsa-miR-101-3p YES YES NO hsa-miR-1297 NO YES NO hsa-miR-132-3p YES YES NO hsa-miR-137 NO YES YES hsa-miR-144-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-192-5p NO YES YES hsa-miR-194-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-215-5p NO YES YES hsa-miR-25-3p NO YES YES hsa-miR-26a-5p NO YES NO hsa-miR-26b-5p NO YES NO hsa-miR-32-5p NO YES YES hsa-miR-363-3p NO YES YES hsa-miR-367-3p NO YES YES hsa-miR-370-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-92a-3p NO YES YES hsa-miR-92b-3p NO YES YES hsa-miR-98-5p NO YES YES Display: