ctcRbase

Entry Detail

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General Information

Database ID: BRCA07535 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: RAF1 Full Name: Raf-1 proto-oncogene, serine/threonine kinase Category: mRNA Synonyms: CMD1NN|CRAF|NS5|Raf-1|c-Raf Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 12583601 End Site(bp): 12664226 Gene Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000132155 HGNC ID: HGNC:9829 Entrez Gene: 5894

Expression Profile of RAF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-149-5p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-362-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-455-5p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-493-3p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES NO YES hsa-miR-7-5p YES YES NO Display: